Data Sets

Theophylline, Warfarin & Monolix

Toy Data Sets

Theophylline, Warfarin, and the Monolix Data Sets are the standard data sets that will be used in this website for examples. Please click on them to see how the each data set was massaged to fit the needs of the functions/examples.

Info

Six data sets: Theophylline, Warfarin x2, and Monolix x3
warfarin.mdvpk.1 was used to generate the examples for the Variations
The Monolix data sets were used to generate the examples for Box Plot,Quantile Plot,Scatter Plot
Each data set was altered from its original condition

Requirements

All 'X' and 'Y' data must be ready to plot, with no filtering necessary, when sent to the plotting function
- Please see the examples throughout the website
DOSE is repeated for each row of each ID
When the Administration happens, the AMT cell must equal the DOSE given (data$AMT==data$DOSE)
Split or subset the data before sending it to the function
- Ex. Warfarin contains both MDVPK==0 and MDVPK==1
- Warfarin was split into both warfarin.mdvpk.0 and warfarin.mdvpk.1
Check to make sure columns have not been repeated
- NONMEM automatically attaches columns to the last four positions unless told not to, this could cause repeated columns
- You might be wanting to use the second column named 'DV', but R interprets the second column as 'DV.1'

Final Forms
of Toy Data Sets

Download theophylline (Final)(Source the file)

> head(theophylline)
  ID DOSE TIME    DV WEIGHT MDV  AMT
1  1 4.02 0.00    NA   79.6   1 4.02
2  1 4.02 0.25  2.84   79.6   0 0.00
3  1 4.02 0.57  6.57   79.6   0 0.00
4  1 4.02 1.12 10.50   79.6   0 0.00
5  1 4.02 2.02  9.66   79.6   0 0.00
6  1 4.02 3.82  8.58   79.6   0 0.00

Download warfarin.mdvpk.1(Source the file)

> head(warfarin.mdvpk.1)
    ID TIME WEIGHT AGE SEX CMT AMT DVID DV MDV MDVPK DOSE
1  100    0   66.7  50   1   1 100    1 NA   1     1  100
10 100   24   66.7  50   1   2   0    2 44   0     1  100
12 100   36   66.7  50   1   2   0    2 27   0     1  100
14 100   48   66.7  50   1   2   0    2 28   0     1  100
16 100   72   66.7  50   1   2   0    2 31   0     1  100
17 100   96   66.7  50   1   2   0    2 60   0     1  100

Download warfarin.mdvpk.0(Source the file)

> head(warfarin.mdvpk.0)
   ID TIME WEIGHT AGE SEX CMT AMT DVID   DV MDV MDVPK DOSE
2 100  0.5   66.7  50   1   2   0    1  0.0   0     0  100
3 100  1.0   66.7  50   1   2   0    1  1.9   0     0  100
4 100  2.0   66.7  50   1   2   0    1  3.3   0     0  100
5 100  3.0   66.7  50   1   2   0    1  6.6   0     0  100
6 100  6.0   66.7  50   1   2   0    1  9.1   0     0  100
7 100  9.0   66.7  50   1   2   0    1 10.8   0     0  100

Download Bolus(source file)

> head(bolus)
  ID TIME     DV   LNDV MDV    AMT EVID   DOSE    V1   CL    Q    V2
1  1 0.00      .      .   1 120000    1 120000 101.5 3.57 6.99 59.19
2  1 0.25 1040.7 6.9476   0      0    0 120000 101.5 3.57 6.99 59.19
3  1 0.50 1629.0 7.3957   0      0    0 120000 101.5 3.57 6.99 59.19
4  1 0.75  877.8 6.7774   0      0    0 120000 101.5 3.57 6.99 59.19
5  1 1.00 1247.2 7.1286   0      0    0 120000 101.5 3.57 6.99 59.19
6  1 1.50 1225.1 7.1107   0      0    0 120000 101.5 3.57 6.99 59.19

Download Infusion(source file)

> head(infuse)
  ID   TIME     DV   LNDV MDV   AMT  RATE EVID  DOSE   V1 CL    Q    V2 SS TAU TMSS
1  1 216.00      .      .   1 60000 60000    1 60000 67.2  4 5.38 54.27  1  24 0.00
2  1 216.25  489.2 6.1927   0     0     .    0 60000 67.2  4 5.38 54.27  .   . 0.25
3  1 216.50  900.8 6.8032   0     0     .    0 60000 67.2  4 5.38 54.27  .   . 0.50
4  1 216.75  999.7 6.9074   0     0     .    0 60000 67.2  4 5.38 54.27  .   . 0.75
5  1 217.00 1360.5 7.2156   0     0     .    0 60000 67.2  4 5.38 54.27  .   . 1.00
6  1 217.50 1154.3 7.0512   0     0     .    0 60000 67.2  4 5.38 54.27  .   . 1.50

Download Oral(source file)

> head(oral)
  ID TIME    DV   LNDV MDV   AMT EVID  DOSE    V1    VM    KM    Q    V2    KA
1  1 0.00     .      .   1 20000    1 20000 94.18 606.5 249.8 6.84 77.56 0.884
2  1 0.25  38.6 3.6525   0     0    0 20000 94.18 606.5 249.8 6.84 77.56 0.884
3  1 0.50  77.2 4.3466   0     0    0 20000 94.18 606.5 249.8 6.84 77.56 0.884
4  1 0.75  99.6 4.6009   0     0    0 20000 94.18 606.5 249.8 6.84 77.56 0.884
5  1 1.00 115.4 4.7486   0     0    0 20000 94.18 606.5 249.8 6.84 77.56 0.884
6  1 1.50 124.8 4.8269   0     0    0 20000 94.18 606.5 249.8 6.84 77.56 0.884

Data Sets

Toy Data Sets

Info

Requirements

Final Formsof Toy Data Sets

Final Forms
of Toy Data Sets